Abstract #3232
Post-contrast myocardial T1 is more sensitive and precise than partition coefficient/ECV to cardiovascular disease: phantom and human validation
Neville D Gai 1 , Fabio Raman 1 , Christopher Sibley 1 , Songtao Liu 1 , and David Bluemke 1,2
1
Radiology & Imaging Sciences, NIH, Bethesda,
Maryland, United States,
2
NIBIB,
Bethesda, Maryland, United States
T1 mapping and derived values such as partition
coefficient and extracellular volume (ECV) have been
used to differentiate normal myocardium from myocardium
with diffuse fibrosis. There is scant theoretical and
experimental evidence to-date favoring one measure over
the other. In this study, we systematically compare the
sensitivity and precision of T1 mapping measures. Using
error analysis and measurements from phantoms, we show
that post-contrast myocardium T1 (T1
cm
) has a
higher precision than derived values like ECV. Comparing
T1
cm
of
normal volunteers with heart failure patients, we show
that T1
cm
has
higher sensitivity to disease discrimination compared
with ECV.
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