Abstract #3267
Quantitative Susceptibility Mapping (QSM) in -amyloid-PET-confirmed Alzheimers Disease at 7T
Andreas Schfer 1 , Solveig Tiepolt 2 , Elisabeth Roggenhofer 1 , Robert Trampel 1 , Carsten Stueber 1 , Vilia Zeisig 2 , Udo Grossmann 2 , Thies H. Jochimsen 2 , Osama Sabri 2 , Turner Robert 1 , and Henryk Barthel 2
1
Max-Planck-Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
2
Department
of Nuclear Medicine, University of Leipzig, Germany
In this study we examined 6 patients with beta-amyloid-PET-confirmed
Alzheimer disease and 10 healthy controls at 7T. Based
on the phase data of a whole brain FLASH sequence with
0.7mm isotropic resolution we calculated the
susceptibility maps. Across the group, QSM values in the
AD patients were significantly increased compared to
healthy controls. The regional analysis showed a
significant increase of QSM values in regions typically
affected in AD. This more paramagnetic behavior could be
due to an increased iron accumulation in brain regions
in Alzheimer disease, which may coincide already with
early plaque formation.
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