Abstract #3268
Quantitative Susceptibility Mapping to assess Iron Levels in Rat Brain Tumors
Casey A Anderson 1 , Kimberly R Pechman 2 , and Kathleen M Schmainda 3,4
1
Biophysics, Medical College of Wisconsin,
Milwaukee, Wisconsin, United States,
2
Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United
States,
3
Radiology, Medical College of
Wisconsin, Milwaukee, WI, United States,
4
Biophysics,
Medical College of Wisconsin, Milwaukee, WI, United
States
With the increased understanding of iron metabolism and
its relationship to cancer, iron-imaging techniques may
provide valuable insight about the underlying physiology
of tumors. While several imaging techniques can quantify
iron, quantitative susceptibility mapping (QSM) is most
dependent on the susceptibility effects from iron while
the others are affected by tissue properties. We
evaluated rat brain tumors with QSM to see if increased
iron is found in the tumors. From the initial findings
of this work, we demonstrate that increased
susceptibility is detectable in rat brain tumors with
QSM, and is a promising means to quantify iron in
tumors.
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