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Abstract #3270

Assessment of Brain Iron Deficiency in Restless Legs Syndrome (RLS) Using Quantitative Susceptibility Mapping at 7T

Xu Li 1,2 , Hongjun Liu 1,3 , Richard Allen 4 , Christopher J Earley 4 , Richard Edden 1,2 , Peter B Barker 1,2 , Tiana Krum 4 , and Peter C.M. van Zijl 1,2

1 F.M. Kirby research center for functional brain imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3 Radiology, Guangdong General Hospital, Guangzhou, Guangdong, China, 4 Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Quantitative susceptibility mapping (QSM) at 7T was utilized to assess possible brain iron deficiency in restless legs syndrome (RLS) (AKA Willis Ekbom disease) using the measured tissue magnetic susceptibility as an iron index. Initial data collected on 14 RLS patients and age-matched normal controls (n=5) showed decreased magnetic susceptibility in RLS patients as compared to controls in substantia nigra, red nucleus, dentate nucleus, globus pallidus and the pulvinar nucleus of thalamus. Among them the difference in dentate nucleus was statistically significant (t test, one sided for directional hypotheses, p<0.05), while there was a trend toward differences in substantia nigra (p<0.12).

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