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Abstract #3271

Detection of demyelination in Multiple Sclerosis using analysis of T2* relaxation at 7T

Xiaozhen Li 1,2 , Peter van Gelderen 1 , Pascal Sati 3 , Jacco A. de Zwart 1 , Daniel S. Reich 3 , and Jeff H. Duyn 1

1 Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, Maryland, United States, 2 Division of Clinical Geriatrics, NVS Dept., Karolinska Institutet, Huddinge, Stockholm, Sweden, 3 Translational Neuroradiology Unit, Neuroimmunology Branch, NINDS, National Institutes of Health, Bethesda, Maryland, United States

Multiple sclerosis (MS) is a chronic disease of the nervous system characterized by focal areas of myelin loss (lesions). Recent gradient-echo studies suggest the possibility of obtaining cellular compartment-specific information from multi-component fitting of the T2* relaxation decay curve, allowing determination of the relative fractions of myelin water, axonal water and interstitial water. Our findings suggested that three-component fitting of the T2* relaxation decay curve in MS lesions may help quantify cumulative myelin loss, and possibly discriminate between chronic and more acute stages of lesion evolution.

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