Abstract #3271
Detection of demyelination in Multiple Sclerosis using analysis of T2* relaxation at 7T
Xiaozhen Li 1,2 , Peter van Gelderen 1 , Pascal Sati 3 , Jacco A. de Zwart 1 , Daniel S. Reich 3 , and Jeff H. Duyn 1
1
Advanced MRI Section, LFMI, NINDS, National
Institutes of Health, Bethesda, Maryland, United States,
2
Division
of Clinical Geriatrics, NVS Dept., Karolinska
Institutet, Huddinge, Stockholm, Sweden,
3
Translational
Neuroradiology Unit, Neuroimmunology Branch, NINDS,
National Institutes of Health, Bethesda, Maryland,
United States
Multiple sclerosis (MS) is a chronic disease of the
nervous system characterized by focal areas of myelin
loss (lesions). Recent gradient-echo studies suggest
the possibility of obtaining cellular
compartment-specific information from multi-component
fitting of the T2* relaxation decay curve, allowing
determination of the relative fractions of myelin water,
axonal water and interstitial water. Our findings
suggested that three-component fitting of the T2*
relaxation decay curve in MS lesions may help quantify
cumulative myelin loss, and possibly discriminate
between chronic and more acute stages of lesion
evolution.
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