Abstract #3272
Oxygen Extraction Fraction Measurement using Quantitative Susceptibility Mapping in Patients with Chronic Cerebral Ischemia: Comparison with Positron Emission Tomography
Kohsuke Kudo 1,2 , Tian Liu 3 , Jonathan Goodwin 2 , Ikuko Uwano 2 , Fumio Yamashita 2 , Satomi Higuchi 2 , Noriyuki Fujima 1 , Yi Wang 3 , Kuniaki Ogasawara 4 , Akira Ogawa 4 , and Makoto Sasaki 2
1
Diagnostic and Interventional Radiology,
Hokkaido University Hospital, Sapporo, Hokkaido, Japan,
2
Ultra-High
Field MRI, Iwate Medical University, Morioka, Iwate,
Japan,
3
Radiology,
Weill Cornell Medical College, NY, United States,
4
Neurosurgery,
Iwate Medical University, Morioka, Iwate, Japan
Oxygen extraction fraction (OEF) represents an important
parameter of brain metabolism. The purposes of this
study are, to establish OEF measurements using
quantitative susceptibility mapping (QSM), and to
compare QSM-OEF with the gold standard PET-OEF in
patients with unilateral chronic steno-occlusive
disease. QSM-OEF value in the affected hemisphere was
significantly higher than the contralateral hemisphere.
Good correlation of OEF ratio between QSM-OEF and PET-OEF
was observed, and the sensitivity and specificity for
the detection of increased OEF by QSM was 0.80 and 0.90,
respectively.
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