Abstract #3279
Role of R2* with BOLD MRI in the Staging of Prostate Cancer
Wenchao Cai 1 , Feiyu Li 1 , Jing Wang 2 , Jue Zhang 3,4 , Xiaoying Wang 1,3 , and Xuexiang Jiang 1
1
Peking University First Hospital, Beijing,
Beijing, China,
2
MRI
Research Center, Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, China,
3
Academy
for Advanced Interdisciplinary Studies, Peking
University, Beijing, China,
4
College
of Engineering, Peking University, Beijing, China
Static blood oxygen level dependent (BOLD) MRI is a
non-invasive method quantitatively measuring R2* which
is sensitive to oxygenation status and accordance to
hypoxia measured by immunohistochemical staining and pO2
microelectrode in prostate cancer. Tumor hypoxia have
negative impact on response to various cancer therapies
and promotion of metastasis. Therefore the purpose of
the study was to investigate the ability of R2* by
static BOLD MRI in staging of prostate tumor, and
compared R2* with blood flow (BF) from ASL. Our results
show a significant drop of R2* along with the prostate
cancer upstaged detected via BOLD MRI, and inverse
correlation between R2* and BF, which indicates that R2*
values in patients with prostate cancer may be highly
dependent on blood oxygenation.
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