Abstract #3292
Accelerated CEST-MRI of in vivo human brain using Compressed Sensing at 3T: a pilot study
Qinwei Zhang 1 , Yanjie Zhu 2 , Jing Yuan 1,3 , Shuzhong Chen 1 , Deyond Siu 1 , Min Deng 1 , Yi-Xiang J Wang 1 , and Dong Liang 2
1
Department of Imaging and Interventional
Radiology, The Chinese University of Hong Kong, Shatin,
N.T., Hong Kong,
2
Paul
C. Lauterbur Research Center for Biomedical Imaging,
Shenzhen Institutes of Advanced Technology, Shenzhen,
Guangdong, China,
3
CUHK
Shenzhen Research Institute, Shenzhen, Guangdong, China
CEST-MRI is a promising molecular imaging technique
while suffers from long scan time and low
contrast-to-noise ratio (CNR) in clinical use. In this
study, we proposed the use of compressed sensing (CS) to
accelerate the CEST-MRI at 3T. Full-sampled CEST-MRI
data of in vivo human brain were retrospectively
under-sampled and reconstructed up to a reduction factor
of four. The CS-reconstructed magnetization transfer
ratio asymmetry and ΔB0 maps showed excellent
consistency with those using normal reconstruction from
full samples. Goodness-of-fit of the CS-reconstructed
Z-spectrum fitting was even better than the fully
sampled one.
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