Ultrafast chemical exchange saturation transfer imaging based on spatiotemporal encoding

CEST MRI can detect low-concentration compounds with exchangeable protons through saturation transfer to water. This technique is generally time-consuming, as it requires acquisition of saturation images at multiple frequencies. EPI is the most common ultrafast MRI approach, but it suffers from artifacts of susceptibility heterogeneities and chemical shift effect. The spatiotemporally encoded (SPEN) method possesses higher built-in immunity to heterogeneity while retaining the temporal and spatial performance of EPI. In this abstract, SPEN is applied to improve the acquisition efficiency and image quality of CEST. The feasibility of CEST SPEN is demonstrated by experiments on creatine solution phantoms.

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