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Abstract #3301

Optimal Control in Fast Exchange ParaCEST

Giaime Rancan 1,2 , Thi Thoa Nguyen 1 , Silvio Aime 2,3 , Markus Schwaiger 4 , and Steffen Glaser 1

1 Technische Universitt Mnchen, Mnchen, Germany, 2 Institute for Advanced Study, Garching, Germany, 3 Universit degli Studi di Torino, Torino, Italy, 4 Klinikum rechts der Isar, Mnchen, Germany

Optimal control algorithms can provide the perfect framework for a facile and flexible tailoring of pulses to experimental conditions in well characterized two or three pool exchange systems. A CEST contrast agent of clinical interest, YbHPDO3A, is considered for presaturation pulse optimization, revealing the non-optimality of standard continuous wave irradiation under the considered energy limitations.

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