Steady-state pulsed Chemical Exchange Saturation Transfer Imaging of creatine in human calf muscle followed by spillover correction evaluation

In skeletal muscle endogenous chemical exchange saturation transfer (CEST) effects are influenced by direct water saturation and magnetization transfer (MT) effects. In this study we present a method which corrects the CEST data from spillover and apply it to in vivo data of human calf muscle. The results are compared with the more common evaluation method - the asymmetry analysis of the Z-spectrum.

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