Abstract #3304
Spillover, MT and R1 corrected chemical exchange saturation transfer (CEST) imaging in ischemic stroke
Hua Li 1 , Zhongliang Zu 1 , Moritz Zaiss 2 , Imad S. Khan 3 , Robert Singer 3 , Daniel F. Gochberg 1 , Peter Bachert 2 , John C. Gore 1 , and Junzhong Xu 1
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
2
Department
of Medical Physics in Radiology, German Cancer Research
Center (DKFZ), Heidelberg, BW, Germany,
3
Section
of Neurosurgery, Geisel School of Medicine at Dartmouth,
Lebanon, NH, United States
CEST provides the ability to detect small solute pools
through indirect measurement of the attenuated water
signals. However, conventional quantification methods
are affected by various confounding factors like MT,
asymmetric MT effects, water longitudinal relaxation,
and RF spillover. In the current study, the three-offset
method and the 1/Z method were combined to correct the
above influences and hence provide a more specific
exchange rate weighted contrast in a rat model of
ischemic stroke. The results demonstrate the
applicability of the inverse Z-spectrum analysis for in
vivo applications. The corrected APT shows more
significant ischemic contrast. This study may provide
insights into improved APT imaging.
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