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Abstract #3306

Simplified simultaneous determination of CEST agent concentration and exchange rate

Phillip Zhe Sun 1 , Gang Xiao 2 , and Renhua Wu 3

1 Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Department of Math and Applied Mathematics, Hanshan Normal University, Guangdong, China, 3 Radiology, 2nd Affiliated Hospital of Shantou University Medical College, Guangdong, China

Simplified quantitative CEST (qCEST) analysis capable of characterizing the underlying CEST system provides tremendous advantage over the conventional CEST-weighted MTR asymmetry analysis. We here postulated that both labile proton ratio and exchange rate can be simultaneously determined using omega plot analysis of a cross-term normalized CEST ratio. The proposed qCEST analysis was validated experimentally in a phantom with concurrent concentration and pH variation. In summary, our study established a simplified qCEST analysis algorithm, which remains promising to aid the ongoing development of qCEST MRI.

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