Abstract #3306
Simplified simultaneous determination of CEST agent concentration and exchange rate
Phillip Zhe Sun 1 , Gang Xiao 2 , and Renhua Wu 3
1
Radiology, Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
Department
of Math and Applied Mathematics, Hanshan Normal
University, Guangdong, China,
3
Radiology,
2nd Affiliated Hospital of Shantou University Medical
College, Guangdong, China
Simplified quantitative CEST (qCEST) analysis capable of
characterizing the underlying CEST system provides
tremendous advantage over the conventional CEST-weighted
MTR asymmetry analysis. We here postulated that both
labile proton ratio and exchange rate can be
simultaneously determined using omega plot analysis of a
cross-term normalized CEST ratio. The proposed qCEST
analysis was validated experimentally in a phantom with
concurrent concentration and pH variation. In summary,
our study established a simplified qCEST analysis
algorithm, which remains promising to aid the ongoing
development of qCEST MRI.
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