Abstract #3307
Assessing Different Amide Proton Transfer (APT) Quantification Methods in Hyper-acute Stroke Patients
Yee Kai Tee 1 , George Harston 2 , Nicholas Blockley 3 , Thomas Okell 3 , Jacob Levman 1 , Martino Cellerini 4 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 1 , and Michael Chappell 1
1
Department of Engineering Science, Institute
of Biomedical Engineering, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
Acute
Stroke Programme, Radcliffe Department of Medicine,
University of Oxford, Oxfordshire, United Kingdom,
3
FMRIB,
Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxfordshire, United Kingdom,
4
Department
of Neuroradiology, Oxford University Hospitals NHS
Trust, Oxfordshire, United Kingdom
Amide proton transfer (APT) imaging is an emerging pH
mapping MRI technique that has potential to identify
salvageable tissue prior to irreversible infarction
after stroke. However, the most widely used APT
quantification method suffers from many confounding
factors. In this study, 3 different APT quantification
methods were studied on data acquired from healthy
subjects and hyper-acute stroke patients (<6 hours of
onset). It was found that a model-based approach, where
the modified Bloch equations were fitted to measured
data, was able to quantify the APT effect better than
the widely used metric on both the healthy and patient
data.
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