Abstract #3309
Amide Proton Transfer (APT) Imaging of Stroke with Corrections for Relaxation and MT effects
Zhongliang Zu 1 , Hua Li 1 , Junzhong Xu 1 , Daniel F Gochberg 1 , and John C Gore 1
1
Vanderbilt University, Nashville, TN, United
States
Conventional measurements of APT contrast are confounded
by several factors including water relaxation, the
influence of solid components, and nearby amines, and so
are not specific for detecting changes in concentration
or exchange rate of amides. These confounding factors
vary during ischemia influence pH measurements. In this
study, a novel method named CERT
ex
is
described which corrects for such factors and produces
images that are more specifically k
sw
(and
thus pH) dependent. Simulations and experiments show
that CERT
ex
has
better specificity and sensitivity than conventional APT
imaging methods for delineating effects of stroke at 9.4
T.
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