Molecular Imaging of Fibrotic Remodeling and Functional Microcirculation using a novel MT/CEST Encoded Steady State Cardiac Cine MRI Pulse Sequence.

Molecular imaging of the heart is critical for detection of early signs of disease and for monitoring response to therapy. We present the development of a steady state retrospectively gated cardiac cine imaging sequence in which the presence of fibrosis or CEST contrast agents was encoded into the myocardial signal intensity. We applied this technique for quantification of fibrotic scar formation in the mouse heart after myocardial infarction, and for imaging of the myocardial microcirculation following intravenous injection of a CEST contrast agent. Since contrast from each target is selectively encoded, this technique can potentially enable multiplexed imaging of multiple molecular targets at high-resolution in the heart.

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