Abstract #3312
Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors
Osamu Togao 1 , Takashi Yoshiura 1 , Jochen Keupp 2 , Akio Hiwatashi 1 , Koji Yamashita 1 , Kazufumi Kikuchi 1 , Yuriko Suzuki 3 , Koji Sagiyama 4 , Masaya Takahashi 4 , and Hiroshi Honda 1
1
Clinical Radiology, Graduate School of
Medical Science, Kyushu University, Fukuoka, Fukuoka,
Japan,
2
Philips
Research Europe, Hamburg, Germany,
3
Philips
Electronics Japan, Tokyo, Japan,
4
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, Texas, United States
APT imaging is a specific type of endogenous CEST
imaging technique. APT imaging can be useful in grading
gliomas, diagnosing radiation necrosis, and evaluation
of therapeutic effect. Observed signal changes in APT
imaging is small and it can be influenced by the
accuracy of saturation pulse and B0 inhomogeneity
correction. We have developed a parallel RF transmission
based technique, which allows arbitrarily long
saturation pulses via amplifier alternation in clinical
scanners. This method is combined with a special RF
shimming for B1 homogeneity. In this study we assessed
the reproducibility of this method in brain tumors by a
scan-rescan test.
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