Abstract #3313
Chemical Exchange Saturation Transfer MR Imaging of Parkinson's Disease at 3 Tesla
Chunmei Li 1 , Shuai Peng 1 , Rui Wang 1 , Haibo Chen 1 , Wen Su 1 , Xuna Zhao 2 , Jinyuan Zhou 3 , and Min Chen 1
1
Beijing Hospital, Beijing, Beijing, China,
2
Peking
University, Beijing, China,
3
Johns
Hopkins University, Maryland, United States
Chemical Exchange Saturation Transfer MR Imaging of
Parkinsons Disease at 3 Tesla This present study was
the first to evaluate PD patients with CEST imaging. Our
results clearly show that the non-invasive CEST MRI
methodology generated unique image contrasts that are
based on the changes in cytoplasmic proteins and
peptides, as well as the neuronal loss in several
specific brain regions in PD patients. The CEST MRI
signals show great potential as imaging biomarkers that
could detect disease and predict the progression.
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