Abstract #3314
Chemical Exchange Saturation Transfer (CEST) Imaging of the Molecular Progression of Neuronal Loss in a Parkinson's Disease Rat Model
Julius Juhyun Chung 1,2 , Sunyoung Chae 1,2 , Moon-sun Jang 3 , Jae-hun Kim 4 , Geun Ho Im 3 , Seong-Gi Kim 2,5 , and Jung Hee Lee 1,4
1
Samsung Advanced Institute for Health
Sciences and Technology, Sungkyunkwan University, Seoul,
Korea,
2
Center
for Neuroscience Imaging Research, Institute for Basic
Sciences, Sungkyunkwan University, Suwon, Korea,
3
Center
for Molecular and Cellular Imaging, Samsung Biomedical
Research Institute, Seoul, Korea,
4
Department
of Radiology, Samsung Medical Center, Seoul, Korea,
5
Department
of Radiology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States
: Despite the growing prevalence of Parkinsons disease,
the progression of neuronal loss in the dopaminergic
nigrostriatal pathway has yet to be fully elucidated. In
this study, we utilize chemical exchange saturation
transfer (CEST) to examine molecular changes in
progressive neuronal loss in a 6-hydroxydopamine induced
rat model. In particular, we examined Amide Proton
Transfer (APT*) and the Nuclear Overhauser Effect (NOE*)
as indicators of macromolecular protein changes and
investigated the additional information that may be
ascertained from Amine Proton EXchange (APEX).
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