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Abstract #3323

APT-CEST and NOE imaging of C6 Glioma cell cultures at 7T

Mona Salehi Ravesh 1 , Judith Becker 1,2 , Kristin Koetz 1 , Amir Moussavi 1 , Gabriele Trompke 1 , Kirsten Hattermann 2 , and Susann Boretius 1

1 Section Biomedical Imaging, Department of Radiology and Neuroradiology, Christian-Albrechts-University, Kiel, Schleswig Holstein, Germany, 2 Anatomical Institute, Christian-Albrechts-University, Kiel, Schleswig Holstein, Germany

Recently interesting amide proton transfer (APT) and nuclear overhause enhancement (NOE) effects were reported from in vivo studies in brain tumors. Here, we wanted to investigate, whether we could reproduce these effects in isolated glioma cells. Comparison of C6 z-spectra with z-spectra of nutrient components indicated that the observed asymmetry was mainly caused by the glucose and fetal bovine serum containing nutrition solution rather than specific metabolic products of the tumor cells. The APT and NOE effects observed in vivo may therefore require a tumor-stoma interaction.

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