Abstract #3323
APT-CEST and NOE imaging of C6 Glioma cell cultures at 7T
Mona Salehi Ravesh 1 , Judith Becker 1,2 , Kristin Koetz 1 , Amir Moussavi 1 , Gabriele Trompke 1 , Kirsten Hattermann 2 , and Susann Boretius 1
1
Section Biomedical Imaging, Department of
Radiology and Neuroradiology,
Christian-Albrechts-University, Kiel, Schleswig
Holstein, Germany,
2
Anatomical Institute,
Christian-Albrechts-University, Kiel, Schleswig
Holstein, Germany
Recently interesting amide proton transfer (APT) and
nuclear overhause enhancement (NOE) effects were
reported from in vivo studies in brain tumors. Here, we
wanted to investigate, whether we could reproduce these
effects in isolated glioma cells. Comparison of C6
z-spectra with z-spectra of nutrient components
indicated that the observed asymmetry was mainly caused
by the glucose and fetal bovine serum containing
nutrition solution rather than specific metabolic
products of the tumor cells. The APT and NOE effects
observed in vivo may therefore require a tumor-stoma
interaction.
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