Abstract #3322
The Amine CEST Feature as a Biomarker of Apoptosis
Martin Durant 1 , Sharon Portnoy 2 , Kimberly L Desmond 1 , Claudia Dziegielewski 2 , Martin P. Stanisz 2 , Anne L Martel 1,2 , and Greg J. Stanisz 1,2
1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
2
Sunnybrook
Research Institute, Toronto, Ontario, Canada
Apoptosis was investigated using Chemical Exchange
Saturation Transfer (CEST). Samples of Acute Myeloid
Leukemia cells were scanned at 7T, half treated with
cisplatin, and half as the untreated control, with CEST
offset frequencies -3000-3000Hz. The most notable
difference is seen in the Amine feature (~2ppm offset),
which is clearly seen in the control, but absent in the
treated spectra. A simple "relative area" measure is
used to quantify the change, which is highly
significant. Some speculation on the possible causes is
given. CEST spectroscopy thus may enable monitoring of
response to agents such as cisplatin.
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