31P Magnetic Resonance Spectroscopy and amide proton transfer-Chemical Exchange Saturation Transfer based probes for intracellular pH measurements at 7 tesla

Poor spatial resolution is the main limitation of phosphorous-31 MRS for intracellular pH (pHi) quantification. A new method for measuring pHi with high spatial resolution is desired. The feasibility of amide proton transfer (APT) pHi measurements was already demonstrated. However, pHi sensitivity of APT was not addressed. To the end, we therefore propose a setup that combines accurate but low resolution 31P MSR with high resolution chemical exchange saturation transfer (CEST) in the quantification of pHi, using the higher spectral resolution and SNR of 7T. The findings of the study suggest that APT contrast is highly pHi sensitive and can be quantified using 31P MRS in the same subject.

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