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Abstract #3320

Validation of APT as a measure of pH by 31P in a piglet model of HIE

Marilena Rega 1 , Francisco Torrealdea 1 , Alan Bainbridge 2 , David L Price 2 , Magdalena Sokolska 1 , Kevin Broad 3 , Go Kawano 3 , Mojgan Ezatti 3 , Igor Fierrens 3 , Aaron Oliver-Taylor 1 , Christina Uria-Avellanal 3 , Simon Walker-Samuel 4 , David L Thomas 1 , Nikola Robertson 3 , and Xavier Golay 1

1 Institute of Neurology, UCL, London, London, United Kingdom, 2 UCLH, London, United Kingdom, 3 Institute for woman's health, UCLH, London, United Kingdom, 4 Centre for Advance Biomedical Imaging, UCL, London, United Kingdom

The present work demonstrates the use of APT-MRI as a measure of local pH changes in a model of Hypoxia ischemia insult in the piglet brain. 31P MRS confirms the pH response seen with APT. This work highlights the advantage of spatial information from local pH variations, which may vary across the brain. This technique has the potential to be used in the clinic to map local pH changes and assess treatment effectiveness in newborns suffering from asphyxiation during birth.

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