Abstract #3319
Intracellular pH Measurement by AACID-CEST MRI at 9.4T: Imaging brain tumor-selective acidification by lonidamine
Nevin McVicar 1,2 , Alex X Li 2 , Susan Meakin 2,3 , and Robert Bartha 1,2
1
Medical Biophysics, University of Western
Ontario, London, Ontario, Canada,
2
Robarts
Research Institute, Ontario, Canada,
3
Biochemistry,
University of Western Ontario, London, Ontario, Canada
Lonidamine is an anticancer drug that selectively
decreases intracellular pH in tumor cells. A ratiometric
CEST approach called amine/amide concentration
independent detection (AACID) was recently developed to
measure absolute intracellular pH in vivo using MRI. In
this study, we produce pH maps before and ~1-2 hour
after injection of lonidamine and then immediately post
mortem in a brain tumor mouse model. Results show that
lonidamine exclusively decreases tumor intracellular pH
by ~0.2 pH units and AACID is capable of mapping local
changes in brain tumor pH in vivo.
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