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Abstract #3325

Chemical Exchange Saturation Transfer (CEST) and Nuclear Overhauser Effect (NOE) in Blood

Shaokuan Zheng 1 , Guoxing Lin 2 , Kajo van der Marel 1 , Zhongliang Zu 3 , Yansong Zhao 4 , and Matthew J Gounis 1

1 Radiology, UMASS Medical School, Worcester, MA, United States, 2 Gustav H. Carlson School of Chemistry, Clark University, Worcester, MA, United States, 3 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 4 Philips Healthcare, Cleveland, OH, United States

In this study, we performed 1H NMR spectroscopy of blood plasma and red blood cells and subsequently applied Lorentzian fitting of the Z-spectrum, in order to distinguish between the Nuclear Overhauser Effect (NOE) signal arising from aliphatic protons and the CEST signal from exchangeable protons. We found that the NOE effect in the plasma and red blood cells is strong and asymmetric, which may introduce errors in conventional analysis of blood CEST data. The effect of saturation power on the CEST and NOE effect is different, so the saturation power can be optimized to reach a maximum MTRasym.

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