Abstract #3325
Chemical Exchange Saturation Transfer (CEST) and Nuclear Overhauser Effect (NOE) in Blood
Shaokuan Zheng 1 , Guoxing Lin 2 , Kajo van der Marel 1 , Zhongliang Zu 3 , Yansong Zhao 4 , and Matthew J Gounis 1
1
Radiology, UMASS Medical School, Worcester,
MA, United States,
2
Gustav
H. Carlson School of Chemistry, Clark University,
Worcester, MA, United States,
3
Institute
of Imaging Science, Vanderbilt University, Nashville,
TN, United States,
4
Philips
Healthcare, Cleveland, OH, United States
In this study, we performed 1H NMR spectroscopy of blood
plasma and red blood cells and subsequently applied
Lorentzian fitting of the Z-spectrum, in order to
distinguish between the Nuclear Overhauser Effect (NOE)
signal arising from aliphatic protons and the CEST
signal from exchangeable protons. We found that the NOE
effect in the plasma and red blood cells is strong and
asymmetric, which may introduce errors in conventional
analysis of blood CEST data. The effect of saturation
power on the CEST and NOE effect is different, so the
saturation power can be optimized to reach a maximum
MTRasym.
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