Abstract #3326
The signature of protein unfolding in CEST imaging in vitro
Steffen Goerke 1 , Moritz Zaiss 1 , Patrick Kunz 2 , Karel D. Klika 3 , and Peter Bachert 1
1
Department of Medical Physics in Radiology,
German Cancer Research Center (DKFZ), Heidelberg,
Baden-Wrttemberg, Germany,
2
Department
of Functional Genome Analysis, German Cancer Research
Center (DKFZ), Heidelberg, Baden-Wrttemberg, Germany,
3
Department
of Molecular Structure Analysis, German Cancer Research
Center (DKFZ), Heidelberg, Baden-Wrttemberg, Germany
Folding states of proteins may have an important
contribution to the NOEmediated contrast in chemical
exchange saturation transfer (CEST) imaging of tumors.
In
1
H
NMR experiments with bovine serum albumin (BSA) under
different denaturing conditions a characteristic
signature of protein folding state in the Zspectrum was
identified. This signature may enable to determine the
extent of changes of Zspectra due to protein unfolding
in
vivo
.
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