Innovative method for the detection of T 1 agents with MTC

In the present work, the possibility to observe the presence of T1 agents by using Magnetization Transfer Contrast (MTC) measurement has been tested since it is well known that MTC depends on the T1 of the tissue. The possibility to observe the same molecule with different MRI sequences will strengthen the evidence of a molecular target when the signal is barely detectable. By looking at the MTC seems to be possible to detect Gd-labeled cells at lower concentration inside a tissue respect to T1 enhancement, especially in the case of compartmentalization of Gd-probe in endosomal vesicles.

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