Innovative method for the detection of T 1 agents with MTC
Giuseppe Ferrauto 1 , Daniela Delli Castelli 1 , Enza Di Gregorio 1 , Enzo Terreno 1 , and Silvio Aime 1
Molecular Biotechnologies & Health Sciences,
Molecular Imaging Center, Torino, Italy
In the present work, the possibility to observe the
presence of T1 agents by using Magnetization Transfer
Contrast (MTC) measurement has been tested since it is
well known that MTC depends on the T1 of the tissue. The
possibility to observe the same molecule with different
MRI sequences will strengthen the evidence of a
molecular target when the signal is barely detectable.
By looking at the MTC seems to be possible to detect Gd-labeled
cells at lower concentration inside a tissue respect to
T1 enhancement, especially in the case of
compartmentalization of Gd-probe in endosomal vesicles.
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