Abstract #3329
Novel Quantitative Magnetization Transfer (qMT) of the Human Optic Nerve in vivo.
Alex K Smith 1,2 , Richard D Dortch 2,3 , and Seth A Smith 2,3
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
3
Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States
Optic nerve damage is related to the eventual
development of MS, and often results in permanent,
visual dysfunction. While qMT has been used to evaluate
tissue microstructure in the brain and spinal cord,
studies in the optic nerve have been limited due to poor
contrast between the optic nerve and surrounding tissue.
The Dixon method has been used for fat/water separation;
however, it has never been applied to the optic nerve,
or for qMT imaging. Here we apply novel qMT utilizing
Dixon fat/water separation for accurate quantification
of the pool size ratio in the human optic nerve in vivo.
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