Abstract #3330
Reproducibility and Sensitivity of Quantitative Magnetization Transfer Imaging in Longitudinal Assessment of Spinal Cord Injuries of Monkey
Feng Wang 1,2 , Ke Li 1,2 , Huixin Qi 3 , Arabinda Mishra 1 , Chaohui Tang 1 , Daniel Gochberg 1,2 , Li Min Chen 1,2 , and John C. Gore 1,2
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
2
Radiology
Department, Vanderbilt University, Nashville, TN, United
States,
3
Psychology
Department, Vanderbilt University, Nashville, TN, United
States
We optimized acquisition schemes for in vivo
quantitative magnetization transfer (qMT) imaging and
evaluated the reproducibility and sensitivity of qMT
parameters for assessing spinal cord injuries (SCI) of
anesthetized squirrel monkeys. The results provided
robust and sensitive parameters to the formation of
abnormalities around the lesion site after SCI. Those
qMT parameters were highly correlated to measures of T1,
ADC and MTRasym. MRI findings were in agreement with
spinal cord tissue histology. This study can help us
understand the formation of tumor, cyst or edema,
demyelination, inflammation and gliosis during the
healing progress after unilateral dorsal column lesion
at cervical spinal cord level.
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