Fast high-resolution whole-brain macromolecular proton fraction mapping using a minimal number of source images

Macromolecular proton fraction (MPF), a key parameter determining the magnetization transfer (MT) effect, has recently attracted significant interest as a biomarker of myelin. Based on a recently published single-point MPF mapping method, a more time-efficient approach has been developed. The described technique eliminates the need in the image for data normalization by using the synthetic reference image calculated from variable flip angle data. Accordingly, only three source images (T1, proton density-, and MT-weighted) are needed for MPF map reconstruction. Based on this principle, whole-brain 3D MPF maps can be obtained with isotropic 1.25 mm resolution and ~20 minutes scan time.

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