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Abstract #3337

High Resolution, Motion Corrected Mapping of Macromolecular Proton Fraction (MPF) In Clinically Acceptable Time Using 3D Undersampled Radials

Alexey Samsonov 1 , Pouria Mossahebi 2 , Ashley Anderson 3 , Julia Velikina 4 , Kevin M. Johnson 4 , Sterling C Johnson 5 , John O Fleming 6 , and Aaron Field 7

1 Radiology, University of Wisconsin, Madison, United States, United States, 2 Biomedical Engineering, University of Wisconsin, Madison, United States, United States, 3 Medical Physics, University of Wisconsin, Madison, WI, United States, 4 Medical Physics, University of Wisconsin, Madison, Wisconsin, United States, 5 Medicine, University of Wisconsin, Madison, Wisconsin, United States, 6 Neurology, University of Wisconsin, Madison, Wisconsin, United States, 7 Radiology, University of Wisconsin, Madison, Wisconsin, United States

Two-pool modeling of magnetization transfer (MT) effects yields a unique set of measures sensitive to different tissue composition properties. The key parameter of interest in this model is a macromolecular pool fraction (MPF), a potential biomarker of myelin in neural tissues. However, traditional MPF mapping within clinical scan time is a relatively low-resolution methodology. The purpose of this work was to develop a clinically feasible, high resolution, motion corrected MPF mapping protocol compatible with clinical standards for GM assessment (~1 mm isotropic, under 30 min).

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