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Abstract #3338

Fat Suppressed Modified Cross Relaxation Imaging of Articular Cartilage using MaTS: Magnetization Transfer Subtraction

Nade Sritanyaratana 1 , Pouria Mossahebi 1 , Walter Block 1 , Alexey Samsonov 2 , and Richard Kijowski 2

1 Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2 Radiology, University of Wisconsin-Madison, Madison, WI, United States

Modified Cross relaxation imaging (mCRI) is a quantitative magnetization transfer (MT) technique that has been shown to provide potentially useful information about cartilage degeneration. However, cartilage imaging, especially in clinical settings, typically requires large slice thicknesses (3-4mm) because cartilages relatively thin tissue structure demands high in-plane resolution (≈0.5mm). Especially since bone and cartilage are significantly curved structures, this highly anisotropic imaging scheme tends to increase partial voluming, and in the context of quantitative imaging can significantly corrupt parametric maps if not corrected. Thus, we propose a technique that suppresses partial voluming from fat and other MT non-exchanging tissues. The proposed technique also suppresses fat chemical shift artifacts, allowing for lower bandwidth imaging for higher SNR.

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