Abstract #3343
Comparison of gradient- and spin-echo DSC PWI image sequences for determination of contrast agent leakage effects
Nils Daniel Forkert 1 , Heiko Schmiedeskamp 1 , Jalal B. Andre 2 , Reena P. Thomas 3 , Seema Nagpal 3 , Lawrence Recht 3 , Nancy Fischbein 1 , and Roland Bammer 1
1
Department of Radiology, Stanford
University, Stanford, CA, United States,
2
Department
of Radiology, University of Washington, WA, United
States,
3
Department of Neurology and
Neurological Sciences, Stanford University, CA, United
States
Blood-brain-barrier disruptions may result in contrast
agent leakage into the extravascular space, which may
hinder a correct determination of perfusion parameters
from DSC perfusion-weighted imaging. Considering that
brain tumors may not only recruit enlarged, angiogenic
vessels, but also smaller microvessels, determining the
leakage effect in spin-echo PWI images may lead to
additional benefits compared to gradient-echo leakage
determination. A first analysis of 10 tumor patient
datasets, including a gradient- and spin-echo sequence,
revealed very high correlation between the leakage
parameters while more pronounced leakage patterns can be
found visually in some tumor regions using leakage
determination in spin-echo images.
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