Abstract #3344
Amide proton transfer (APT)-MRI signal as a biomarker for assessment of glioma response to radiotherapy
Xiaohua Hong 1,2 , Meiyun Wang 1 , Kai Ding 3 , Bo Ma 1 , Antonella Mangraviti 4 , Betty Tyler 4 , and Jinyuan Zhou 1
1
Department of Radiology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
Cancer
Center, Union Hospital, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan, Hubei,
China,
3
Department
of Radiation Oncology, Johns Hopkins University School
of Medicine, Baltimore, MD, United States,
4
Department
of Neurosurgery, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
We applied several functional and molecular MRI
modalities to U87MG tumor-bearing rats that were treated
with radiation therapy (40 Gy or 20 Gy). Our results
show that tumor ADC, blood flow, and APT were all useful
imaging biomarkers by which to predict glioma response
to radiotherapy. The APT signal was most promising for
early response assessment in this model.
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