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Abstract #3361

Differentiating radiation effect and necrosis from tumor with measures of normalized and standardized relative cerebral blood volume

Melissa A Prah 1 , Mona M Al-Gizawiy 1 , Wade M Mueller 2 , and Kathleen M Schmainda 1,3

1 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 3 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

In brain tumor patients, pseudoprogression, which results from an inflammatory response associated with necrotic and radiation induced changes, has been shown to mimic early tumor progression on standard imaging. Relative cerebral blood volume measures have shown promise in differentiating radiation necrosis and tumor. Through pre-surgical imaging and spatially correlated biopsy samples, this work demonstrates that both normalized and standardized relative cerebral blood volume measures can distinguish radiation necrosis from tumor with equally high sensitivity and specificity. The results of this study may be useful for the creation of tumor burden maps, which could ultimately affect the course of patient treatment.

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