Abstract #3362
Different spatial distribution between GCB and non-GCB PCNSL revealed by MR group analysis of 100 cases.
Manabu Kinoshita 1,2 , Takashi Sasayama 3 , Yoshitaka Narita 4 , Fumio Yamashita 5 , Atsushi Kawaguchi 6 , Naoya Hashimoto 2 , and Toshiki Yoshimine 2
1
Neurosurgery, Osaka Medical Center for
Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan,
2
Neurosurgery,
Osaka University Graduate School of Medicine, Suita,
Osaka, Japan,
3
Neurosurgery,
Kobe University Graduate School of Medicine, Hyogo,
Japan,
4
National
Cancer Center Hospital, Neurosurgery and Neuro-Oncology,
Tokyo, Japan,
5
Division
of Ultrahigh Field MRI, Iwate Medical University, Iwate,
Japan,
6
Biostatistics
Center, Kurume University, Fukuoka, Japan
MR based group analysis is a powerful tool to elucidate
pathological conditions in the brain that are
challenging to be revealed by single subject analysis.
The presented research aimed to elucidate special
distribution characteristics of primary central nervous
system lymphoma (PCNSL) within the brain with respect to
its molecular marker expression patterns. GCB lymphomas
located at around the posterior portion of the white
matter surrounding the lateral ventricles and the
cerebellum around the 4th ventricle, while non-GCB
lymphomas tended to occupy the anterior portion of the
white matter surrounding the lateral ventricles. This is
the very first report that addresses phenotypical and
spatial distributional difference between GCB and non-GCB
PCNSL.
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