1H MRS for in vivo detection of 2-hydroxyglutarate in brain tumors at 1.5T: A numerical simulation study

2-Hydroxyglutarate (2HG) is produced in gliomas with IDH mutations. Given the diagnostic and prognostic value of 2HG and the high availability of 1.5T MR scanners in clinics, the capability of detecting 2HG at 1.5T in-vivo is of high significance. Here we report a computer simulation study for 2HG detection at 1.5T. Synthetic spectra of 15 metabolites with random noises were generated at TE = 20, 66, and 143 ms for various 2HG concentrations and the 2HG detectability was examined with spectral fitting. The 2HG concentrations were well reproduced, suggesting that in-vivo detection of 2HG is highly feasible at 1.5T.

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