Lactate detection in non-enhancing brain of patients with Glioblastoma Multiforme using selective multiple quantum filtered CSI
Lisa M Harris 1 , Nina Tunariu 1 , Christina Messiou 1 , Toni Wallace 1 , Julie Hughes 1 , Nandita M deSouza 1 , Martin O Leach 1 , and Geoffrey S Payne 1
CRUK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research and Royal Marsden Hospital,
Sutton, Surrey, United Kingdom
Glioblastoma multiforme (GBM) is an aggressive brain
tumour, active tumour potentially goes unrecognized as
it may invade further than is visible on standard MRI.
Recognition of tumoral infiltration extent potentially
could improve treatment outcome. This study presents
work applying a selective homonuclear multiple quantum
coherence transfer (SelMQC) sequence in a group of GBM
tumours to assess lactate concentration. Lactate was
seen in the surrounding tissue of some patients, all of
whom had recently completed radiotherapy. Two
conclusions could be possible, either the surrounding
lactate is from infiltrating tumour or lactate in the
periphery maybe an effect of radiation induced hypoxia.
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