Can ADC and Mean Diffusivity derived from DWI and DTI be used interchangeably in patients with glioblastoma?
Melissa A Prah 1 , L.Tugan Muftuler 2 , and Kathleen M Schmainda 1,3
Radiology, Medical College of Wisconsin,
Milwaukee, WI, United States,
Medical College of Wisconsin, Milwaukee, WI, United
Biophysics, Medical College of
Wisconsin, Milwaukee, WI, United States
As part of the standard imaging protocol for brain
tumors, a directionally independent measure of the
apparent diffusion coefficient (ADC) can be derived from
diffusion-weighted imaging (DWI). Additionally,
diffusion tensor imaging (DTI), which incorporates the
direction of gradient vectors, can be used to calculate
ADC, referred to as mean diffusivity (MD). However, when
DTI is acquired, DWI is still appended to the same
scanning session based simply on historical practices.
This work demonstrates that ADC derived from DTI or DWI
can be used interchangeably in evaluating glioblastoma
multiforme, thereby addressing time and cost-saving
measures associated with redundancy in image
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