Abstract #3367
Parametric response maps of perfusion MRI may identify recurrent glioblastomas responsive to bevacizumab and irinotecan
Domenico Aquino 1 , Anna Luisa Di Stefano 2 , Alessandro Scotti 1 , Lucia Cuppini 1 , Elena Anghileri 3 , Gaetano Finocchiaro 3 , Maria Grazia Bruzzone 1 , and Marica Eoli 3
1
Neuroradiology, Fondazione IRCCS Istituto
Neurologico Carlo Besta, Milan, Italy,
2
General
Neurology, IRCCS Istituto Neurologico Nazionale
C.Mondino, Pavia, Italy,
3
Molecular
Neuro-Oncology, Fondazione IRCCS Istituto Neurologico
Carlo Besta, Milan, Italy
Perfusion weighted imaging may be useful in the early
assessment of response to angiogenesis inhibitors. Aim
of this work is to compare Parametric Response Maps with
the Region Of Interest approach in the analysis of tumor
changes induced by bevacizumab and irinotecan in 42
recurrent glioblastomas, and to evaluate if changes in
tumor CBV measured by perfusion MRI may predict clinical
outcome. An increased CBV (> 18%) in PRM after 8 weeks
of treatment was associated with increased PFS and OS.
The presence of two non-contiguous lesions and
multifocal disease at baseline were independent
predictors of shorter PFS and OS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
