Towards Pathoneurochemical Profiling of Multiple Sclerosis: Single-Session Measurement of Glutathione, GABA and Glutamate with MR Spectroscopy at 7 Tesla

Glutathione (GSH), GABA, and glutamate are assumed to play key roles in the onset and progression of multiple sclerosis (MS). We report their measurement in a single 1-hour session establishment of J-difference editing and STEAM MR spectroscopy (MRS) twice in five healthy individuals and once in an MS patient (along with other MS-relevant neurochemicals such as NAA, myo-inositol, creatine, and cholines). The implementation is expected to serve as a tool for clinical MS research, patient monitoring, and treatment control.

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