Abstract #3378
Quantification of GABA in the grey matter in Multiple Sclerosis
Niamh Cawley 1 , Bhavana Solanky 2 , Nils Muhlert 3 , CAM Wheeler-Kingshott 2 , A.J Thompson 1,4 , and Olga Ciccarelli 1,5
1
Dept. Brain Repair & Rehabilitation, QS MS
Centre, UCL Institute of Neurology, London, United
Kingdom,
2
Department
of Neuroinflammation, QS MS Centre, UCL Institute of
Neurology, London, United Kingdom,
3
Cognitive
Neuroscience, Cardiff, United Kingdom,
4
NIHR
UCL-UCLH Biomedical Research Centre, London, United
Kingdom,
5
NIHR
UCL-UCLH Biomedical Reserach Centre, London, United
Kingdom
In this study we have provided quantification of GABA
concentration in the hippocampus, prefrontal cortex and
sensorimotor cortex in patients with secondary
progressive MS in comparison to healthy controls using
the MEGA-PRESS 1H MRS at 3T. Patients showed reduced
[GABA+] levels in the hippocampus and in the sensori-motor
cortex, compared to controls. We then looked to see if
[GABA+] was associated with cognitive impairment in the
hippocampus and motor and sensory function in the
sensori-motor cortex. There was a significant
association between grip strength and [GABA+] in the
sensori-motor cortex as well as muscle strength using
the MRC scoring system.
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