Effect of affected / unaffected eye viewing on visual cortex GABA - fMRI correlation in patients with optical neuritis

Increased task-related cortical activation in multiple sclerosis (MS) has been reported to be correlated with gamma amino butyric acid (GABA) level in sensorimotor as well as visual cortex. This has been attributed to possible role of GABA in cortical adaptation in MS. We studied 8 MS patients with optical neuritis to investigate whether the impairment of specific eye has any effect on the correlation of GABA with activation. We observe that the correlation is independent of the impairment of the eye suggesting potential role of GABA in cortical adaptation is a general phenomenon in MS.

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