Differential involvement of GABA and Glx in fMRI activation of visual cortex in patients with optical neuritis

Increased task-related cortical activation in multiple sclerosis (MS) has been reported to be correlated with inhibitory neurotransmitter gamma amino butyric acid (GABA) level in sensorimotor as well as visual cortex. This has been attributed to possible role of GABA in cortical adaptation in MS. We studied 8 MS patients with optical neuritis (ON) to investigate the involvement of GABA and excitatory glutamate (plus glutamine, together known as glx) in activation along nasal and temporal pathways. We observed a difference in the involvement of glx along the two pathways, while GABA involvement remained the same.

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