Differential involvement of GABA and Glx in fMRI activation of visual cortex in patients with optical neuritis
Pallab K Bhattacharyya 1 , Blessy Mathew 1 , Bharath Atthe 1 , Mark Lowe 1 , and Robert Bermel 1
Cleveland Clinic, Cleveland, OH, United
Increased task-related cortical activation in multiple
sclerosis (MS) has been reported to be correlated with
inhibitory neurotransmitter gamma amino butyric acid
(GABA) level in sensorimotor as well as visual cortex.
This has been attributed to possible role of GABA in
cortical adaptation in MS. We studied 8 MS patients with
optical neuritis (ON) to investigate the involvement of
GABA and excitatory glutamate (plus glutamine, together
known as glx) in activation along nasal and temporal
pathways. We observed a difference in the involvement of
glx along the two pathways, while GABA involvement
remained the same.
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