MRI measured brain and spinal cord atrophy differ between mouse strains in a murine model of MS
M. Mateo Paz Soldan 1 , Jeffrey D. Gamez 1 , Mekala Raman 1 , Slobodan I. Macura 2 , Aaron J. Johnson 3 , and Istvan Pirko 1
Department of Neurology, Mayo Clinic,
Rochester, MN, United States,
and NMR Core Facility, Mayo Clinic, Rochester, MN,
Department of Immunology, Mayo
Clinic, Rochester, MN, United States
Multiple sclerosis pathology is characterized by
demyelination, axonal loss and neuronal damage.
Neurologic disability correlates with axonal loss and
atrophy. Using in vivo MRI, we established a time course
of brain and spinal cord atrophy in a murine MS model,
and correlated that with functional disability. Mouse
strains with spontaneous remyelination show limited
atrophy and disability, while mouse strains without
remyelination display progressive atrophy and
disability. Brain atrophy occurs early while spinal cord
atrophy is delayed. Both correlate strongly with
disability. Remyelination is a key component of
axonal/neuronal survival, which likely explains improved
functional and radiological outcomes in this model.
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