Abstract #3383
High-resolution brain imaging in mice with acute and chronic experimental autoimmune encephalomyelitis
Thomas W. Johnson 1 , Nabeela Nathoo 1 , Ying Wu 1 , James A. Rogers 2 , and Jeff F. Dunn 1,3
1
Radiology, University of Calgary, Calgary,
Alberta, Canada,
2
Clinical
Neurosciences, University of Calgary, Calgary, Alberta,
Canada,
3
Experimental
Imaging Centre, Calgary, Alberta, Canada
High-resolution MRI of mice with experimental autoimmune
encephalomyelitis (EAE), a mouse model of MS, was
performed using a cryogenically-cooled RF coil. Gross
anatomical differences were found in the peak mice,
where cerebellar cross-sectional area and dorso-lateral
distance were increased. Long-term EAE mice had sizes
intermediate between controls and peak-EAE mice. In
addition, a novel anoxic sacrifice method of
increasing blood vessel contrast was used. A trend of
increased blood vessel size was seen in some peak EAE
mice, indicating a neuroinflammatory cause. These data
show the potential for using high resolution MR and our
novel sacrifice method for looking at changes in gross
anatomy and blood vessels in mouse brain.
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