Abstract #3384
Detection of demyelination of the sensory and motor cortex in a mild EAE mouse model using diffusion weighted MRI
Othman I Alomair 1,2 , Nematullah Khan 3 , Maree Smith 3,4 , Ian M Brereton 1 , Graham J Galloway 1 , and Nyoman D Kurniawan 1
1
Centre for Advanced Imaging, University of
Queensland, Brisbane, Queensland, Australia,
2
College
of Applied medical Science, King Saud University,
Riyadh, Riyadh Province, Saudi Arabia,
3
School
of Pharmacy, University of Queensland, Brisbane,
Queensland, Australia,
4
Centre
for Integrated Preclinical Drug Development, University
of Queensland, Brisbane, Queensland, Australia
Cortical gray matter demyelination is a potential
hallmark of Multiple Sclerosis. Here we describe the use
of high spatial and angular resolution ex vivo
diffusion-weighted imaging (HARDI) to investigate
neuropathological changes in the brains of our mild EAE-mouse
model of remitting-relapsing MS.
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