Abstract #3385
MRI detection of pial and subpial abnormalities in the multiple sclerosis spinal cord
Hugh Kearney 1 , Marios C Yiannakas 1 , Rebecca S Samson 1 , Claudia A.M. Wheeler-Kingshott 1 , Olga Ciccarelli 1,2 , and David H. Miller 1,2
1
NMR Research Unit, UCL Institute of
Neurology, London, United Kingdom,
2
NIHR
University College London Hospitals Biomedical Research
Centre, London, United Kingdom
Meningeal inflammation has been proposed to cause
subjacent parenchymal demyelination in multiple
sclerosis ( MS). We therefore investigated the outermost
region of the spinal cord containing pia mater and
subpial tissue using magnetisation transfer (MT)
imaging. In healthy controls, MTR was higher in the
outer spinal cord compared to cord white matter, which
may reflect an effect of collagen in the spinal cord pia
mater. In MS we found a decrease in MTR in this region,
which occurred early in the disease course, prior to
significant cord atrophy.
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