Abstract #3387
High-Resolution Metabolic Neuroimaging
William D Rooney 1 , Manoj K. Sammi 1 , Xin Li 1 , Brendan Moloney 1 , Yosef A. Berlow 1 , Dennis N. Bourdette 2 , and Charles S. Springer, Jr. 1
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Neurology,
Oregon Health & Science University, Portland, Oregon,
United States
Current metabolic imaging methods suffer from spatial
resolution poorer than desired. Shutter-speed
pharmacokinetic analyses of DCE-MRI data provides the
mean capillary water lifetime, tau
b
, with ~1
mm resolution. Here, we show the first ever tau
b
maps
for the normal and MS human brains. By comparison with
another pharmacokinetic biomarker and with other
metabolic imaging results, we show that tau
b
is
inversely proportional to on-going neuronal Na
+
/K
+
ATPase
activity. This activity is decreased in the MS brain.
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