Abstract #3388
Myelin Water Fraction Change within White Matter Lesions May Predict Conversion of Clinically Isolated Syndrome to Definite Multiple Sclerosis
Hagen H Kitzler 1 , Hannes Wahl 1 , Jason Su 2 , Henning Schmitz-Peiffer 3 , Ziemssen Tjalf 3 , Sean C Deoni 4 , and Brian K Rutt 2
1
Neuroradiology Department, Technische
Universitaet, Dresden, SN, Germany,
2
Radiology
Department, Stanford University, Palo Alto, CA, United
States,
3
Neurology
Department, Technische Universitaet, Dresden, SN,
Germany,
4
Engineering
Department, Brown University, Providence, RI, United
States
Within this study we investigated the discrimination of
Clinically Isolated Syndrome patients from healthy
controls using mcDESPOT, a whole-brain relaxation method
that allows the evaluation of WM myelination by means of
measuring myelin water fraction. An ordinarily hidden
relationship between CIS and subtle WM myelination
changes before the conversion to definite MS was
established and a correlation between the time since
symptom onset and decreasing brain parenchymal volume
suggested early global tissue changes reflected by
volume measures. A strong effect of lesional MWF changes
on the odds to convert to MS, although not significant,
may reflect a potential predictor.
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