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Abstract #3388

Myelin Water Fraction Change within White Matter Lesions May Predict Conversion of Clinically Isolated Syndrome to Definite Multiple Sclerosis

Hagen H Kitzler 1 , Hannes Wahl 1 , Jason Su 2 , Henning Schmitz-Peiffer 3 , Ziemssen Tjalf 3 , Sean C Deoni 4 , and Brian K Rutt 2

1 Neuroradiology Department, Technische Universitaet, Dresden, SN, Germany, 2 Radiology Department, Stanford University, Palo Alto, CA, United States, 3 Neurology Department, Technische Universitaet, Dresden, SN, Germany, 4 Engineering Department, Brown University, Providence, RI, United States

Within this study we investigated the discrimination of Clinically Isolated Syndrome patients from healthy controls using mcDESPOT, a whole-brain relaxation method that allows the evaluation of WM myelination by means of measuring myelin water fraction. An ordinarily hidden relationship between CIS and subtle WM myelination changes before the conversion to definite MS was established and a correlation between the time since symptom onset and decreasing brain parenchymal volume suggested early global tissue changes reflected by volume measures. A strong effect of lesional MWF changes on the odds to convert to MS, although not significant, may reflect a potential predictor.

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